Case report: A case of chronic cluster headache affected by gender affirmation treatment

Case report: A case of chronic cluster headache affected by gender affirmation treatment

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Background Chronic cluster headache (CH) affects around one in 10,000 people, some of them are resistant to a multitude of treatments.Case We present a case report of a patient with grandpas best treatment resistant chronic CH which has significantly improved in the setting of gender-affirming care and hormonal treatment with cyproterone acetate and estradiol.Conclusion The case contributes to a growing body of literature suggesting that hormonal factors may impact the clinical course of primary headache disorders, including CH.Particularly in the context of transgender patients and hormone replacement click here therapy, hormonal modulation may offer an adjunct or alternative approach for managing chronic and treatment-resistant headaches.